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KMID : 0984920140160020107
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Journal of Skin Barrier Research
2014 Volume.16 No. 2 p.107 ~ p.107
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Inhibition of TRPV1 Channel by Constituents of the Rhizome of Cyperus rotundus
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Nam Joo-Hyun
Lee Dong-Ung
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Abstract
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Cyperus rotundus (Cyperaceae) is used as an analgesic and sedative in oriental medicine, and has been reported to exhibit anti-nociceptive and anti-inflammatory effects. On the other hand, transient receptor potential vanilloid channel 1 (TRPV1) is a nonselective cation channel that senses various noxious chemical and thermal stimuli. However, it has recently been reported that epidermally expressed TRPV1 is involved in heat- and UV-induced skin aging. The aim of this study was to evaluate whether Cyperus rotundus extract and its constituents inhibit TRPV1. Ethylacetate and hexane fractions of the methanol extract were found to partially inhibit TRPV1 activity, and at a concentration of 90 μM oleanolic acid, which was one of three constituents isolated from the ethylacetate fraction, inhibited TRPV1 activity by 61.4 ± 8.0 %. This is first electrophysiological study to be conducted on the effects of Cyperus rotundus extract and of their constituents on TRPV1. The results obtained provide insight of the potential therapeutic effects of Cyperus rotundus in the contexts of analgesia and UV-induced photoaging.
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KEYWORD
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Cyperus rotundus, Cyperaceae, TRPV1 channel, Oleanolic acid
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